Ammonia → HCID 178426206, compound

HRID 1988132Notes

Reaction equation

HRID 1988132 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[CH2:11][C@H:10]([N:12]3[CH2:16][CH2:15][CH2:14][C@H:13]3[CH3:17])[CH2:9]2)=[CH:4][CH:3]=1.[NH3:18]>>[CH3:17][CH:13]1[CH2:14][CH2:15][CH2:16][N:12]1[C@H:10]1[CH2:11][C@H:8]([C:5]2[CH:6]=[CH:7][C:2]([C:2]3[CH:7]=[CH:6][C:5]([C:8]#[N:18])=[CH:4][CH:3]=3)=[CH:3][CH:4]=2)[CH2:9]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178461415HCID 178461415, compound

Product 1

HCID 178426206HCID 178426206, compound

Procedure

The title compound was prepared using the procedure described in Example 2B except substituting the product from the Example 4A for the product from Example 2A. 1H NMR (300 MHz, CD3OD) δ 1.24 (d, J=6 Hz, 3 H), 1.60 (m, 1 H), 1.90 (m, 2 H), 2.12 (m, 1 H), 2.41 (m, 1 H), 2.53 (m, 1 H), 2.70 (m, 3 H), 2.92 (m, 1 H), 3.24 (m, 1 H), 3.62 (m, 2 H), 7.46 (d, J=9 Hz, 2 H), 7.67 (d, J=9 Hz, 2 H), 7.80 (s, 4H); (DCl/NH3) m/z 317 (M+H)+.

Sources & evidence

ORD record
ord-1fdfa68f981d4bef896260fc32ba467b
Source dataset
uspto-grants-2009_06
Patent number
US07553964B2

Reaction notes

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