Diazomethane → HCID 53969069, compound

HRID 1988186Notes

Reaction equation

HRID 1988186 reaction equation
[F:1][C:2]([F:10])([F:9])[C@:3]([OH:8])([CH3:7])[C:4]([OH:6])=[O:5].[N+](=[CH2:13])=[N-]>CCOCC>[F:1][C:2]([F:10])([F:9])[C@:3]([OH:8])([CH3:7])[C:4]([O:6][CH3:13])=[O:5]

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 7019028(2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid

Product 1

HCID 53969069HCID 53969069, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of (S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid (3.0 g, 17.4 mmol) in 60 ml of ether was added a solution of diazomethane in ether until a yellow coloration remained. The reaction mixture was then stirred 30 min at room temperature and concentrated to dryness to afford the title compound. 1H NMR (400 MHz, acetone-d6): δ 5.67 (s, 1H), 3.85 (s, 3H), 1.57 (s, 3H).

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-432e92ed0e994064af957311574dc2ae
Source dataset
uspto-grants-2009_06
Patent number
US07553973B2

Reaction notes

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