反应详情

温度

0 °C

A solution of (4-bromo-2-methoxy-5-methylphenyl)(4-fluorophenyl)methanone (1.80 g, 5.57 mmol) in CH2Cl2 (6 mL) was added over 10 min to a 0° C. solution of BBr3 (1.05 mL, 11.1 mmol) in the same solvent (14 mL) and the resulting mixture was stirred at 0° C. After 1.5 h, the reaction mixture was poured into 200 mL of ice-water, vigorously stirred for 10 min and extracted with CHCl3 (3×). The combined organic extracts were washed with water and brine, dried (Na2SO4) and concentrated, affording the title compound. 1H NMR (500 MHz, acetone-d6): δ 11.46 (s, 1H), 7.88 (m, 2H), 7.58 (s, 1H), 7.37 (m, 2H), 7.32 (s, 1H), 2.34 (s, 3H).

1. stirringvigorously stirred for 10 min
2. extractionextracted with CHCl3 (3×)
3. washThe combined organic extracts were washed with water and brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated