反应详情

(4-Bromo-2-hydroxy-5-methylphenyl)(4-fluorophenyl)methanone (1.61 g, 5.21 mmol) and methyl(triphenylphosphoranylidene)acetate (2.26 g, 6.77 mmol) were heated in refluxing toluene (15 mL) for 24 h. The reaction mixture was allowed to cool to rt and concentrated. The yellow solid obtained was subjected to column chromatography on silica gel (EtOAc-toluene, 0% to 2%) to afford the title compound. 1H NMR (500 MHz, acetone-d6): δ 7.70 (s, 1H), 7.66 (m, 2H), 7.46 (s, 1H), 7.39 (m, 2H), 6.39 (s, 1H), 2.40 (s, 3H).

1. concentrationconcentrated
2. customThe yellow solid obtained