反应详情

To a solution of 7-(hydroxymethyl)-4-(2-methyl-1,3-thiazol-4-yl)-2H-chromen-2-one (0.387 g, 1.42 mmol) in CH2Cl2 (7 ml) was added MnO2 (1.85 g, 21.2 mmol) and stirred at rt for 4 h. A second portion of MnO2 (1.85 g, 21.2 mmol) was added and 3 h later the reaction mixture was filtered on celite, evaporated to dryness and purified by trituration in CH2Cl2-MeOH (9:1) to give the title compound. 1H NMR (400 MHz, acetone-d6): δ 10.12 (s, 1H), 8.45 (m, 1H), 8.31 (s, 1H), 7.95 (s, 1H), 7.85 (m, 1H), 6.9 (s, 1H), 2.80 (s, 3H).

1. filtrationwas filtered on celite
2. customevaporated to dryness
3. custompurified by trituration in CH2Cl2-MeOH (9:1)