Potassium Cyanide → 5-(1-(Benzyloxycarbonylamino)-2-(3-tert-butyl-4-hydroxylphenyl)ethyl)imidazolidine-2,4-dione

Participants

Reaction Conditions

Reaction Steps

To a solution of Z-Tyr(3-tBu)-H (2.18 g, 6.14 mmol) in ethanol (25 ml), potassium cyanide (480 mg, 7.37 mmol), 30% ammonium carbonate (1.77 g, 18.4 mmol) and water (25 ml) were added and stirred at 60° C. for 8 hours. The mixture was left for cooling and mixed with a saturated aqueous NaHCO3 solution. The organic layer was extracted with ethyl acetate and washed with water and then with saturated brine, dried over anhydrous magnesium sulfate and evaporated to remove the solvent under reduced pressure; the thus obtained residue was subjected to silica gel column chromatography (developing solvent: ethyl acetate:n-hexane=1:1), giving the titled compound (1.38 g, 53%).

Provenance & Evidence