HRID1988274

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)C(C(=O)NC(Cc1ccc(O)c(C(C)(C)C)c1)c1ncno1)N(C)C(=O)C(Cc1ccc(F)cc1)NC(=O)OC(C)(C)C

HCID86760902

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)C(C(=O)NC(Cc1ccc(O)c(C(C)(C)C)c1)c1ncno1)N(C)C(=O)C(N)Cc1ccc(F)cc1

HCID86760901

未命名化合物

收率 99.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

To a solution of 2-((2-tertbutoxycarbonylamino-3-(4-fluorophenyl)propionyl)-N-methylamino)-3-methylbutyric acid 2-(3-t-butyl-4-hydroxyphenyl)-1-(1,2,4-oxadiazol-5-yl)ethylamide (440 mg) in methylene chloride (5 ml), TFA (1 ml) was added under cooling with ice. The mixture was stirred at room temperature for 1 hour and evaporated to remove the solvent under reduced pressure; the thus obtained residue was subjected to silica gel column chromatography (developing solvent: methylene chloride:methanol=15:1), giving the titled compound (370 mg, 99%).

WORKUP

后处理

temperatureunder cooling with ice
customevaporated
customto remove the solvent under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-27bfe7723119483db72387433a7fc2a4
来源数据集: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07553969B1
来源说明: uspto-grants-2009_06

反应SMILES

[C:1]([C:5]1[CH:6]=[C:7]([CH2:12][CH:13]([NH:19][C:20](=[O:46])[CH:21]([N:25]([C:27](=[O:45])[CH:28]([NH:37]C(OC(C)(C)C)=O)[CH2:29][C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[CH3:26])[CH:22]([CH3:24])[CH3:23])[C:14]2[O:18][N:17]=[CH:16][N:15]=2)[CH:8]=[CH:9][C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2]>C(Cl)Cl.C(O)(C(F)(F)F)=O>[C:1]([C:5]1[CH:6]=[C:7]([CH2:12][CH:13]([NH:19][C:20](=[O:46])[CH:21]([N:25]([C:27](=[O:45])[CH:28]([NH2:37])[CH2:29][C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[CH3:26])[CH:22]([CH3:24])[CH3:23])[C:14]2[O:18][N:17]=[CH:16][N:15]=2)[CH:8]=[CH:9][C:10]=1[OH:11])([CH3:3])([CH3:4])[CH3:2]