反应详情

A mixture of Tyr(3-tBu)-OMe (12.4 g, 49 mmol) and concentrated aqueous ammonia (240 ml) was stirred at room temperature for 18 hours. The reaction mixture was concentrated under reduced pressure and the thus obtained residue was subjected to silica gel column chromatography (CHCl3:MeOH=10:1), giving Tyr(3-tBu)-NH2 (T1) (10 g, 80%).

1. concentrationThe reaction mixture was concentrated under reduced pressure