HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide → 4-acetoxy-3,5-dimethoxy-N-[(4-aminophenyl)methyl]-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide | HCID 21918554 | — |
| Reactant | 4-acetoxy-3,5-dimethoxy-N-[(4-nitrophenyl)methyl]-benzamide | HCID 21918609 | — |
| Product | 4-acetoxy-3,5-dimethoxy-N-[(4-aminophenyl)methyl]-benzamide | HCID 21918739 | 82% |
Reaction Steps
The experimental protocol used is the same as that described for intermediate 2.2, 4-acetoxy-3,5-dimethoxy-N-[(4-nitrophenyl)methyl]-benzamide replacing the 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-[(4-nitrophenyl)methyl]-benzamide. A colourless oil is obtained with a yield of 82%. The product is used directly in the following stage without additional purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553976B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-a78ed1e1929f4085acd2355c31e17b33 |
| Source note | uspto-grants-2009_06 |