HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-(2-Bromo-acetyl)-2-chloro-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Methyl 5-acetyl-2-chlorobenzoate | HCID 58818179 | — |
| Catalyst | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-(2-Bromo-acetyl)-2-chloro-benzoic acid methyl ester | HCID 58818185 | 102.2% |
Reaction Steps
To a solution of 5-acetyl-2-chloro-benzoic acid methyl ester (100 mg, 0.47 mmol) in glacial acetic acid (5 mL) was added bromine (0.05 mL, 0.94 mmol). The mixture was stirred at room temperature for 2 h. Hydrobromic acid-acetic acid (2 drops, 30%) was added and the mixture was stirred for 10 minutes. The mixture was concentrated in vacuo to afford the title compound (140 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553972B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-8924183b1f654745bf1ae6750523d990 |
| Source note | uspto-grants-2009_06 |