HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 20033286, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Nitrophenethyl methanesulfonate | HCID 21973884 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20033286 | HCID 20033286 | 44% |
Reaction Steps
Methanesulfonic acid 2-(3-nitro-phenyl)-ethyl ester was dissolved in piperidine (20 eq) and THF and stirred at 60° C. for one hour. The solvent was removed. The crude product was diluted with ethyl acetate, washed three times with water, dried with anhydrous sodium sulfate, filtered and concentrated. The product was clean enough to carry forward without purification. 44% yield. MH+=235.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07553854B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-7c1d35cd72af4d05bd43f19442dd3692 |
| Source note | uspto-grants-2009_06 |