HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1988424Generated: October 25, 2026
Cyclohexanemethylamine → 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide
https://huagongshe.com/reaction/1988424
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyclohexanemethylamine | HCID 76688 | — |
| Reactant | 2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]- | HCID 57725393 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide | HCID 57725483 | — |
Reaction Steps
To the solution of 4-(2-methanesulfinyl-benzothiazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (25 mg, 0.072 mmol, 1.0 eq) in DMF (500 μL), was added cyclohexylmethylamine (18.7 μL, 0.144 mmol, 2.0 eq) and reaction was stirred at 70° C. overnight. The neat reaction mixture was purified on reverse phase preparatory HPLC. Pure fractions were lyophilized as TFA salts. M+H=397.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07553854B2 |
|---|
| Source dataset | uspto-grants-2009_06 |
|---|
| ORD ID | ord-63e2180c9de546b2866ba6d1d1ccd679 |
|---|
| Source note | uspto-grants-2009_06 |
|---|
