Diisopropylethylamine → N-methyl-4-(2-(4-((4-methylpiperazin-1-yl)methyl)benzylamino)benzo[d]thiazol-6-yloxy)picolinamide

https://huagongshe.com/reaction/1988478

関与物質

役割	名称	HCID	仕込み量
反応物	Diisopropylethylamine	HCID 81531	—
反応物	4-((4-Methyl-1-piperazinyl)methyl)benzenemethanamine	HCID 7537610	—
反応物	2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]-	HCID 57725393	—
溶媒	N-methyl-2-pyrrolidone	HCID 13387	—
生成物	N-methyl-4-(2-(4-((4-methylpiperazin-1-yl)methyl)benzylamino)benzo[d]thiazol-6-yloxy)picolinamide	HCID 57725947	—

反応条件

温度	80 °C

反応手順

To the solution of N-methyl-4-(2-(methylsulfinyl)benzo[d]thiazol-6-yloxy)picolinamide (25 mg, 0.072 mmol, 1.0 eq) in 2 mL of NMP was added (4-((4-methylpiperazin-1-yl)methyl)phenyl)methanamine (23 mg, 0.108 mmol, 1.5 eq) and DIPEA (37 μL, 0.216 mmol, 3.0 eq) and reaction mixture heated at 80° C. in oil bath for 12 hours. Thereafter, the product was purified via reverse phase HPLC. LC/MS (m/z) [503.1] (MH+).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07553854B2
出典データセット	uspto-grants-2009_06
ORD ID	ord-663d11ea073447a2920cb78d1f4eab3c
出典メモ	uspto-grants-2009_06