Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1988479생성일: 2026년 10월 25일
2-[2-(4-Methylpiperazin-1-yl)ethoxy]aniline → N-methyl-4-(2-(2-(2-(4-methylpiperazin-1-yl)ethoxy)phenylamino)benzo[d]thiazol-6-yloxy)picolinamide
https://huagongshe.com/reaction/1988479
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-[2-(4-Methylpiperazin-1-yl)ethoxy]aniline | HCID 23008788 | — |
| 반응물 | 2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]- | HCID 57725393 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | N-methyl-4-(2-(2-(2-(4-methylpiperazin-1-yl)ethoxy)phenylamino)benzo[d]thiazol-6-yloxy)picolinamide | HCID 57725420 | — |
반응 단계
To the solution of N-methyl-4-(2-(methylsulfinyl)benzo[d]thiazol-6-yloxy)picolinamide (25 mg, 0.072 mmol, 1.0 eq) in 1 mL of IPA and 1 mL conc. HCl was added 2-(2-(4-methylpiperazin-1-yl)ethoxy) aniline (25 mg, 0.108 mmol, 1.5 eq) and reaction mixture heated at 80° C. in oil bath for 2 hours. Thereafter, the product was purified via reverse phase HPLC. This procedure was generalized for other analogues for which progress of the reaction was monitored by LC-MS and amount of aniline and reaction time adjusted as needed. LC/MS (m/z) [519.1] (MH+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07553854B2 |
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| 출처 데이터셋 | uspto-grants-2009_06 |
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| ORD ID | ord-8515f26b3c1b49b6a95b65fddc0d980e |
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| 출처 메모 | uspto-grants-2009_06 |
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