反应详情

A mixture of ethyl {4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}acetate (0.92 g, 2.61 mmol), sodium hydroxide (114 mg, 2.85 mmol), in ethanol (10 ml) and water (10 ml) was stirred at reflux for 1 hour. The reaction mix was allowed to cool and the ethanol was removed under reduced pressure and the residue was made acidic with 5N HCl, then extracted into dichloromethane. The organic layer was added to a 5 g pre-packed column and eluted from 0-100% ethyl acetate in petroleum ether to give the title compound as a pale yellow solid (0.42 g, 50%).

1. temperatureat reflux for 1 hour
2. additionThe reaction mix
3. temperatureto cool
4. customthe ethanol was removed under reduced pressure
5. extractionextracted into dichloromethane
6. additionThe organic layer was added to a 5 g pre-packed column
7. washeluted from 0-100% ethyl acetate in petroleum ether