3-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole → 1-{4-[3-oxo-3-(1-pyrrolidinyl)propyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

HRID 1988658Notes

Reaction equation

HRID 1988658 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[O:11])=[CH:4][CH:3]=1.[F:17][C:18]([F:29])([F:28])[C:19]1[C:27]2[CH2:26][CH2:25][CH2:24][CH2:23][C:22]=2[NH:21][N:20]=1>>[O:11]=[C:10]([N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1)[CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([N:21]2[C:22]3[CH2:23][CH2:24][CH2:25][CH2:26][C:27]=3[C:19]([C:18]([F:17])([F:29])[F:28])=[N:20]2)=[CH:3][CH:4]=1

Participants

3

Reactant 2

HCID 28028633-(Trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazoleHCID 577627853-(4-Bromophenyl)-1-(pyrrolidin-1-yl)propan-1-one

Product 1

HCID 248271411-{4-[3-oxo-3-(1-pyrrolidinyl)propyl]phenyl}-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole

Procedure

The title compound was prepared from 1-[3-(4-bromophenyl)propanoyl]pyrrolidine and 3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole using a similar procedure to that described for Example 19.

Sources & evidence

ORD record
ord-45defc369a8a43c693ad1577f5f3ae0f
Source dataset
uspto-grants-2010_01
Patent number
US07642256B2

Reaction notes

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