HCID 22380352, compound → HCID 22380078, compound

HRID 1988758Notes

Reaction equation

HRID 1988758 reaction equation
[CH2:1]([NH:3][C:4]1[C:5]([N+:13]([O-])=O)=[CH:6][C:7]([C:10](=[O:12])[CH3:11])=[N:8][CH:9]=1)[CH3:2]>C(O)C.[Pd]>[NH2:13][C:5]1[C:4]([NH:3][CH2:1][CH3:2])=[CH:9][N:8]=[C:7]([C:10](=[O:12])[CH3:11])[CH:6]=1

Participants

4

Reactant 1

HCID 22380352HCID 22380352, compound

Product 1

HCID 22380078HCID 22380078, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 1-(5-ethylamino-4-nitro-pyridin-2-yl)-ethanone (310 mg, 1.5 mmol) and 10% Pd/C (50 mg) in ethanol (10 mL) is stirred under hydrogen for 1 hr. The mixture is filtered through Celite and concentrated in vacuo to give the product as yellow solid. 1H NMR (CD3OD) δ 7.61 (s, 1H), 7.30 (s, 1H), 3.26 (q, 2H), 2.53 (s, 3H), 0.90 (t, 3H). LRMS 180.5 (MH+).

Workup

  1. filtrationThe mixture is filtered through Celite
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-079d999adbaf417795f55a2938254966
Source dataset
uspto-grants-2010_01
Patent number
US07642267B2

Reaction notes

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