(2-Methoxypyridin-3-yl)boronic acid → HCID 178494096, compound

Participants

Reaction Steps

In a similar manner to Example 33, Step 1, the Suzuki coupling reaction of the bromide from Step 1 of Example 37 (111 mg, 0.41 mmol) and (2-methoxy-pyridin-3-yl)-boronic acid (125 mg, 0.817 mmol) afforded the 4-[3-(2-methoxy-pyridin-3-yl)-phenyl]-1H-imidazol-2-ylamine, after passing through an SPE ion-exchange plug, as a colorless glass (37.5 mg, 34.4% yield). LC/MS (m/z 267.0 (M+H)+); HPLC Rt: 2.2 min.

Provenance & Evidence