참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | methyl 4-[(1H-benzoimidazol-1-yl)methyl]benzoate | HCID 2823606 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-(1H-benzimidazol-1-ylmethyl)benzoic acid | HCID 2735444 | — |
반응 단계
A solution of methyl 4-((1H-benzo[d]imidazol-1-yl)methyl)benzoate (0.25 mmol) in dioxane (1 mL) was treated with aqueous LiOH (1 M, 1.0 mL). After stirring at 23° C. for 2 h, the reaction was neutralized with aqueous HCl (1 M, 2.0 mL) and the resulting solid was isolated by filtration. The filter cake was rinsed with water and allowed to dry in vacuo to yield 4-((1H-benzo[d]imidazol-1-yl)methyl)benzoic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07642275B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_01 |
|---|
| ORD ID | ord-a5d6f7c1c49243b7a9081d25eff14914 |
|---|
| 출처 메모 | uspto-grants-2010_01 |
|---|
