反应详情

A solution of 1,2-dihydro-1-(1-naphthalenyl)-5H-tetrazole-5-thione (50.0 mg, 0.22 mmol), 2-chloro-1-(2,3-epoxypropyl)benzene (36.9 mg, 0.22 mmol) and Et3N (0.15 mL, 1.10 mmol) in MeOH (5 mL) was heated at reflux for 2 h. The mixture was concentrated under reduced pressure and the residue was purified by HPLC using a gradient of MeCN/H2O containing TFA (0.1%) (CombiPrep ODS-AQ 50×20 mm, 5μ, 120 Å). The pure fractions were concentrated to give the title compound (12 mg, 14% yield) as a colorless solid.

1. temperatureat reflux for 2 h
2. concentrationThe mixture was concentrated under reduced pressure
3. customthe residue was purified by HPLC
4. additioncontaining TFA (0.1%) (CombiPrep ODS-AQ 50×20 mm, 5μ, 120 Å)
5. concentrationThe pure fractions were concentrated