Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 5-Bromoisatin | HCID 6889 | — |
| Reactant | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178517024 | HCID 178517024 | 392.3% |
Reaction Steps
A mixture of 5-bromo-1H-indole-2,3-dione (1.0 g, 0.442 mmol) and 3-trifluoromethylaniline (0.993 g, 6.2 mmol) in a solution of 1% acetic acid in methanol was stirred at 50° C. for 12 h. The crude product was concentrated in vacuo, giving the desired crude product (640 mg, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07642281B2 |
|---|
| Source dataset | uspto-grants-2010_01 |
|---|
| ORD ID | ord-379b50286e624355892627778ad24765 |
|---|
| Source note | uspto-grants-2010_01 |
|---|
