関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Phenylisatin | HCID 12884 | — |
| 反応物 | 5-Amino-2-chloropyridine | HCID 79305 | — |
| 生成物 | 3-[(6-Chloro-3-pyridinyl)imino]-1-phenyl-1,3-dihydro-2H-indol-2-one | HCID 9996959 | 59% |
反応手順
1-Phenylisatin (23.0 mg, 0.10 mmol) and 5-amino-2-chloropyridine (12.8 mg, 0.10 mmol) were mixed and heated at 140° C. for 7 h. The resulting crude product was purified by preparative TLC using hexane/ethyl acetate (8:2) as the eluent, giving the desired product as a yellow solid (19.7 mg, 59%). 1H NMR (400 MHz) δ 8.15 (d, J=8, 1H), 7.6-7.2 (m, 9H), 6.85-6.75 (m, 2H); ESI-MS m/z found 334 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07642281B2 |
|---|
| 出典データセット | uspto-grants-2010_01 |
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| ORD ID | ord-ad84a0b6fcf64352877d7591182c4435 |
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| 出典メモ | uspto-grants-2010_01 |
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