Benzenemethanol, 2-ethoxy- (9CI) → 4-[(2-Ethoxyphenyl)methoxy]-3-nitropyridine

HRID 1988845Notes

Reaction equation

HRID 1988845 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[CH2:11]([O:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][OH:17])[CH3:12]>>[CH2:11]([O:13][C:14]1[CH:21]=[CH:20][CH:19]=[CH:18][C:15]=1[CH2:16][O:17][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9])[CH3:12]

Participants

3

Reactant 2

HCID 51381Benzenemethanol, 2-ethoxy- (9CI)HCID 27357814-Chloro-3-nitropyridine

Product 1

HCID 686994514-[(2-Ethoxyphenyl)methoxy]-3-nitropyridineYield 65.9%

Procedure

In accordance with the same procedures as in Preparation 2, except for using 4-chloro-3-nitropyridine prepared in Step 1 of Preparation 1 and 2-ethoxybenzyl alcohol, the titled compound was obtained as a yellow solid. (Yield: 65.9%)

Workup

  1. customIn accordance with the same procedures as in Preparation 2

Sources & evidence

ORD record
ord-f299e3a440e24a7d8759b36c84e7f08c
Source dataset
uspto-grants-2010_01
Patent number
US07642269B2

Reaction notes

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