反应详情

温度

50 °C

4-hydroxy-3-nitropyridine (40 g, 0.285 mol) was added to 200 ml of water and then bromine (18.44 ml, 0.36 mol) was slowly added thereto at room temperature. The reaction mixture was stirred under heating for 2 hours at 50° C. and then cooled to room temperature. The resulting precipitate was filtered, washed with water, and then dried to give the titled compound as a pale yellow solid (49.8 g, 87.8%). The product was used in the subsequent step without further purification.

1. customat room temperature
2. temperaturecooled to room temperature
3. filtrationThe resulting precipitate was filtered
4. washwashed with water
5. customdried