Bromine → C5H3BrN2O3

HRID 1988856Notes

Reaction equation

HRID 1988856 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[Br:11]Br>O>[Br:11][C:7]1[CH:6]=[N:5][CH:4]=[C:3]([N+:8]([O-:10])=[O:9])[C:2]=1[OH:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 178526806HCID 178526806, compound

Product 1

HCID 178526805C5H3BrN2O3Yield 87.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

4-hydroxy-3-nitropyridine (40 g, 0.285 mol) was added to 200 ml of water and then bromine (18.44 ml, 0.36 mol) was slowly added thereto at room temperature. The reaction mixture was stirred under heating for 2 hours at 50° C. and then cooled to room temperature. The resulting precipitate was filtered, washed with water, and then dried to give the titled compound as a pale yellow solid (49.8 g, 87.8%). The product was used in the subsequent step without further purification.

Workup

  1. customat room temperature
  2. temperaturecooled to room temperature
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-00d670ba9eff4160b68341c5711885f9
Source dataset
uspto-grants-2010_01
Patent number
US07642269B2

Reaction notes

Loading…