反应详情

Cyclopropylamine (1.6 ml) was added dropwise to an ice-old solution of 4-bromo-2-fluoro-N-hydroxybenzenecarboximidoyl chloride (Intermediate 51) (0.59 g) in dry ether (25 ml) under nitrogen. After the addition the mixture was allowed to warm to room temp. then stirred for 18 h. The resulting precipitate was collected by filtration then purified by column chromatography on silica eluting with cyclohexane:ethyl acetate (3:2) to give the title compound as a white solid (0.435 g).

1. additionAfter the addition the mixture
2. temperatureto warm to room temp.
3. filtrationThe resulting precipitate was collected by filtration
4. customthen purified by column chromatography on silica eluting with cyclohexane:ethyl acetate (3:2)