Water → 4-Bromo-1-[(4-fluorobenzene-1-sulfonyl)methyl]-2-nitrobenzene

Participants

Reaction Steps

A suspension of oxone (3.55 g) in water (8 ml) was added to a solution of (4-bromo-2-nitrophenyl)methyl 4-fluorophenyl sulfide (Intermediate 66) (0.52 g) in acetonitrile (10 ml). The mixture was stirred for 5 h filtered and the residue was washed with ethyl acetate. The biphasic filtrate was separated, the aqueous layer was re-extracted with ethyl acetate (2×50 ml) and the combined organic extracts were washed with aqueous sodium metabisulphite (5%, 100 ml) and brine. The dried (MgSO4) extracts were concentrated under vacuum to give the title compound (0.56 g).

Provenance & Evidence