反应详情

A suspension of oxone (7.94 g) in water (16 ml) was added to a solution of (4-bromo-2-nitrophenyl)methyl methyl sulfide (Intermediate 72) (0.52 g) in acetonitrile (20 ml). The mixture was stirred for 5 h filtered and the residue was washed with ethyl acetate. The biphasic filtrate was separated, the aqueous layer was re-extracted with ethyl acetate (2×50 ml) and the combined organic extracts were washed with aqueous sodium metabisulphite (5%, 100 ml) water and brine. The solution was dried using a hydrophobic filter tube then concentrated under vacuum to give the title compound (0.35 g).

1. filtrationfiltered
2. washthe residue was washed with ethyl acetate
3. customThe biphasic filtrate was separated
4. extractionthe aqueous layer was re-extracted with ethyl acetate (2×50 ml)
5. washthe combined organic extracts were washed with aqueous sodium metabisulphite (5%, 100 ml) water and brine
6. customThe solution was dried
7. concentrationthen concentrated under vacuum