HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-3-methyl-1,2-benzoxazole → N-[4-Methyl-3-(3-methyl-1,2-benzisoxazol-6-yl)phenyl]thiophene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-3-methyl-1,2-benzoxazole | HCID 12411322 | — |
| Reactant | N-[4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-thiophenecarboxamide | HCID 21914662 | — |
| Product | N-[4-Methyl-3-(3-methyl-1,2-benzisoxazol-6-yl)phenyl]thiophene-3-carboxamide | HCID 10450424 | 49.3% |
Reaction Steps
Example 5 was prepared in a similar manner to Example 4 using 6-bromo-3-methyl-1,2-benzisoxazole (11 mg) and N-[4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-thiopheneamide (Intermediate 15, 17 mg) to give an oil (8.5 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642276B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-616b354f8f0c425ea046b94f7471e7ec |
| Source note | uspto-grants-2010_01 |