HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-3-methyl-1,2-benzoxazole → 4-Methyl-3-(3-methyl-1,2-benzisoxazol-6-yl)-N-(3-morpholin-4-ylphenyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-3-methyl-1,2-benzoxazole | HCID 12411322 | — |
| Reactant | 4-methyl-N-[3-(4-morpholinyl)phenyl]-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide | HCID 59791521 | — |
| Product | 4-Methyl-3-(3-methyl-1,2-benzisoxazol-6-yl)-N-(3-morpholin-4-ylphenyl)benzamide | HCID 10432676 | 45.2% |
Reaction Steps
Example 7 was prepared in a similar manner to Example 4 using 6-bromo-3-methyl-1,2-benzisoxazole (11 mg) and 4-methyl-N-(3-morpholin-4-yl-phenyl)-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 9, 21 mg) to give the title compound as an oil (9.6 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642276B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-d443d8c7b4824d348053dc4c42e66a17 |
| Source note | uspto-grants-2010_01 |