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HRID1988916

反应详情

EQUATION

反应方程式

HRID 1988916 的结构方程式

REACTANTS

反应物

2
结构：Cc1noc2cc(Br)ccc12
HCID12411322

6-Bromo-3-methyl-1,2-benzoxazole

C8H6BrNO

结构：Cc1ccc(C(=O)Nc2nccs2)cc1B1OC(C)(C)C(C)(C)O1
HCID21914517

未命名化合物

2 次

PRODUCTS

生成物

1
结构：Cc1ccc(C(=O)Nc2nccs2)cc1-c1ccc2c(C)noc2c1
HCID10450480

4-Methyl-3-(3-methyl-1,2-benzisoxazol-6-yl)-N-(1,3-thiazol-2-yl)benzamide

C19H15N3O2S

收率 7.5%

PROCEDURE

实验过程

Example 8 was prepared in a similar manner to Example 4 using 6-bromo-3-methyl-1,2-benzisoxazole (11 mg) and N-(thiazol-2-yl)-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (Intermediate 18, 17 mg) followed by purification via mass directed autoprep to give the title compound as an oil (1.3 mg).

WORKUP

后处理

  1. customfollowed by purification via mass