反应详情

4-Methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-N-(thiazol-2-yl)-benzamide (Intermediate 18, 50 mg), DME (3 ml), aqueous sodium carbonate (1M, 2 ml), tetrakis(triphenylphosphine)palladium (20 mg) and 6-bromo-3-piperidin-4-yl-1,2-benzisoxazole (44 mg, 147 μmol) were heated together at 80° C. under nitrogen for 18 h. The solvent was evaporated, and the residue was purified by column chromatography on silica (10 g) eluting with dichloromethane:ethanol:ammonia (100:8:1) to give the title compound (43 mg).

1. customThe solvent was evaporated
2. customthe residue was purified by column chromatography on silica (10 g)
3. washeluting with dichloromethane:ethanol:ammonia (100:8:1)