4-Methylbenzylamine → N-Cyclopropyl-4-methyl-3-[1-(2-{[(4-methylphenyl)methyl]amino}-2-oxoethyl)-1H-indazol-5-yl]benzamide

HRID 1988943Notes

Reaction equation

HRID 1988943 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23]([O:25]C)=O)[N:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][NH2:34])=[CH:31][CH:30]=1>>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:8]=[CH:9][C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23]([NH:34][CH2:33][C:32]3[CH:35]=[CH:36][C:29]([CH3:28])=[CH:30][CH:31]=3)=[O:25])[N:17]=[CH:16]4)[CH:12]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 660354-MethylbenzylamineHCID 58656497HCID 58656497, compound

Product 1

HCID 58656471N-Cyclopropyl-4-methyl-3-[1-(2-{[(4-methylphenyl)methyl]amino}-2-oxoethyl)-1H-indazol-5-yl]benzamide

Procedure

Example 126 was prepared by General Method D using methyl (5-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-1H-indazol-1-yl)acetate Example 117) and 4-methylbenzylamine to give the title compound (0.010 g)

Workup

  1. customExample 126 was prepared by General Method D

Sources & evidence

ORD record
ord-b1f43fbec37045d5831131097b27cc51
Source dataset
uspto-grants-2010_01
Patent number
US07642276B2

Reaction notes

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