4-Methylbenzylamine → N-Cyclopropyl-3-fluoro-4-methyl-5-[1-(2-{[(4-methylphenyl)methyl]amino}-2-oxoethyl)-1H-indazol-5-yl]benzamide

HRID 1988949Notes

Reaction equation

HRID 1988949 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[C:9]([F:28])[C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23](OC)=[O:24])[N:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[CH3:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34][NH2:35])=[CH:32][CH:31]=1>>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23]([NH:35][CH2:34][C:33]3[CH:36]=[CH:37][C:30]([CH3:29])=[CH:31][CH:32]=3)=[O:24])[N:17]=[CH:16]4)[C:10]([CH3:27])=[C:9]([F:28])[CH:8]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 660354-MethylbenzylamineHCID 58656520HCID 58656520, compound

Product 1

HCID 58656456N-Cyclopropyl-3-fluoro-4-methyl-5-[1-(2-{[(4-methylphenyl)methyl]amino}-2-oxoethyl)-1H-indazol-5-yl]benzamide

Procedure

Example 133 was prepared by General Method D using methyl (5-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-1H-indazol-1-yl)acetate (Example 123) and 4-methylbenzylamine to give the title compound (0.011 g).

Workup

  1. customExample 133 was prepared by General Method D

Sources & evidence

ORD record
ord-04634a8eb84a49de80d0c955ba2806ab
Source dataset
uspto-grants-2010_01
Patent number
US07642276B2

Reaction notes

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