HRID1988951

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16777071

未命名化合物

结构：COC(=O)Cn1ncc2cc(-c3cc(C(=O)NC4CC4)cc(F)c3C)ccc21

HCID58656520

未命名化合物

PRODUCTS

生成物

结构：CNC(=O)c1ccc(CNC(=O)Cn2ncc3cc(-c4cc(C(=O)NC5CC5)cc(F)c4C)ccc32)cc1

HCID58656478

未命名化合物

PROCEDURE

实验过程

Example 135 was prepared by General Method D using methyl (5-{5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl}-H-indazol-1-yl)acetate (Example 123) and 4-(aminomethyl)-N-methylbenzamide to give the title compound (0.005 g).

WORKUP

后处理

customExample 135 was prepared by General Method D

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6a02a93017c741ec908d455b144cc27f
来源数据集: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07642276B2
来源说明: uspto-grants-2010_01

反应 SMILES

[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[C:9]([F:28])[C:10]([CH3:27])=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23](OC)=[O:24])[N:17]=[CH:16]4)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.[NH2:29][CH2:30][C:31]1[CH:40]=[CH:39][C:34]([C:35]([NH:37][CH3:38])=[O:36])=[CH:33][CH:32]=1>>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[C:19](=[CH:20][CH:21]=3)[N:18]([CH2:22][C:23]([NH:29][CH2:30][C:31]3[CH:32]=[CH:33][C:34]([C:35]([NH:37][CH3:38])=[O:36])=[CH:39][CH:40]=3)=[O:24])[N:17]=[CH:16]4)[C:10]([CH3:27])=[C:9]([F:28])[CH:8]=2)[CH2:3][CH2:2]1