Acetic Anhydride → N-(3-fluoro-2-methylphenyl)acetamide

Participants

Reaction Steps

1-amino-3-fluoro-2-methylbenzene (1 equivalent) was dissolved in CH2C2 and acetic anhydride (2.0 equivalents) was added slowly. The solution was stirred at room temperature for 4 hours. The reaction mixture was then quenched with water, and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with H2O, a 10% HCl solution, H2O, and brine. It was then dried over Na2SO4 and concentrated in vacuo, to yield N-(3-fluoro-2-methylphenyl)acetamide as a pink solid. LC/MS (m/z) 168.2 (MH+), Rt 1.91 minutes.

Provenance & Evidence