Sodium Hydroxide → HCID 68682576, compound

HRID 1988988Notes

Reaction equation

HRID 1988988 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15]C(=O)C)=[C:11]([N+:19]([O-:21])=[O:20])[CH:10]=2)[CH2:3]1.[OH-].[Na+]>CO>[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[C:11]([N+:19]([O-:21])=[O:20])[CH:10]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68678821HCID 68678821, compound

Product 1

HCID 68682576HCID 68682576, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-[4-(1-methyl(3-piperidyloxy))-2-nitrophenyl]acetamide was dissolved in 1:1 MeOH:6N NaOH (aq) solution (0.03 M). After stirring at room temperature for 2 hours, MeOH was removed in vacuo. The remaining solution was extracted with EtOAc (3×). The combined organic extracts were then dried over Na2SO4 and concentrated in vacuo to give 4-(1-methyl(3-piperidyloxy))-2-nitrophenylamine.

Workup

  1. customMeOH was removed in vacuo
  2. extractionThe remaining solution was extracted with EtOAc (3×)
  3. dry with materialThe combined organic extracts were then dried over Na2SO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4fe9db81df5244f7b86ef4c424ff731e
Source dataset
uspto-grants-2010_01
Patent number
US07642278B2

Reaction notes

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