N,N-dimethyl-p-phenylenediamine → HCID 16059274, compound

Participants

Reaction Steps

Using the procedure outlined in Example 1(g) the title compound was prepared from 4-dimethylaminoaniline (5 μL, 0.036 mmol) and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 1(e) above, 15 mg, 0.036 mmol). 7.9 mg of 2-(4-dimethylamino-phenylamino)-8-indan-5-yl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a yellow solid. 1H NMR (400 MHz, CDCl3) δ (ppm): 9.31 (br, 1H), 8.53 (s, 1H), 7.82 (d, 1H), 7.61 (br, 1H), 7.41 (d, 1H), 7.29 (s, 1H), 7.17 (d, 1H), 6.76 (d, 1H), 6.46 (br, 2H), 4.39 (q, 2H), 3.03 (m, 4H), 2.89 (s, 6H), 2.22 (m, 2H), 1.37 (t, 3H). Mass Spectrum (LCMS, ESI pos.) Calcd. For C27H27N5O3: 470.21 (M+H), Found: 470.4.

Provenance & Evidence