3-(4-Methylpiperazin-1-yl)aniline → HCID 68678605, compound

Participants

Reaction Steps

Using the procedure outlined in Example 1(g) the title compound was prepared from 3-(4-methyl-piperazin-1-yl)-phenylamine (50 mg, 0.27 mmol) and 8-indan-5-yl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 1(e) above, 100 mg, 0.24 mmol). The title compound was obtained as a yellow solid (60 mg, 46%). 1H NMR (400 MHz, CDCl3) δ (ppm): 9.29 (s, 1H), 8.44 (s, 1H), 7.49 (br, 1H), 7.31 (d, J=7.9 Hz, 1H), 7.20 (m, 2H), 7.09 (d, J=7.8 Hz, 1H), 6.94 (d, J=7.9 Hz, 1H), 6.87 (br, 1H), 6.52 (d, J=7.9 Hz, 1H), 4.32 (q, J=7.1 Hz, 2H), 3.02-2.90 (m, 8H), 2.45 (m, 4H), 2.26 (s, 3H), 2.14 (m, 2H), 1.32 (t, J=7.1 Hz, 3H).

Provenance & Evidence