1-Fluoro-3-nitrobenzene → HCID 68678107, compound

HRID 1989054Notes

Reaction equation

HRID 1989054 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-])=O)[CH:3]=1.[CH3:11][CH:12]1[NH:17][CH:16]([CH3:18])[CH2:15][NH:14][CH2:13]1>>[CH3:18][CH:16]1[NH:17][CH:12]([CH3:11])[CH2:13][N:14]([C:2]2[CH:3]=[C:4]([NH2:8])[CH:5]=[CH:6][CH:7]=2)[CH2:15]1

Participants

3

Reactant 2

HCID 98231-Fluoro-3-nitrobenzeneHCID 660562,6-Dimethylpiperazine

Product 1

HCID 68678107HCID 68678107, compound

Procedure

Using the procedure outlined in Example 37 (A), the title compound was prepared from 1-fluoro-3-nitrobenzene (1 g, 7 mmol) and 3,5-dimethyl-piperazine (1.14 g, 10 mmol). 1H NMR (400 MHz, CDCl3) δ (ppm): 7.00 (t, J=8.0 Hz, 1H), 6.33 (d, J=8.2 Hz, 1H), 6.21 (m, 1H), 6.15 (d, J=8.2 Hz, 1H), 3.60 (br, 2H), 3.45 (d, J=9.8 Hz, 2H), 2.98 (m, 1H), 2.22 (t, J=11.3 Hz, 2H), 1.10 (s, 3H), 1.08 (s, 3H).

Sources & evidence

ORD record
ord-67f92ad1d731469f96e49c9bf6e00716
Source dataset
uspto-grants-2010_01
Patent number
US07642270B2

Reaction notes

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