4-(4-Methylpiperazin-1-yl)aniline → HCID 16059408, compound

Participants

Reaction Steps

Using the procedure outlined in Example 1(g) the title compound was prepared from 4-(4-methyl-piperazin-1-yl)-phenylamine (50 mg, 0.26 mmol) and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 17(e), 100 mg, 0.26 mmol). The title compound was obtained as a yellow solid (80 mg, 63%). 1H NMR (400 MHz, CDCl3) δ (ppm): 9.25 (s, 1H), 8.44 (s, 1H), 7.56 (br, 1H), 7.43 (d, J=8.9 Hz, 2H), 6.87 (d, J=9.0 Hz, 2H), 5.00 (m, 1H), 4.32 (q, J=7.1 Hz, 2H), 3.16 (t, J=4.9 Hz, 4H), 2.55 (t, J=4.9 Hz, 4H), 2.30 (s, 3H), 1.94 (m, 4H), 1.76 (m, 1H), 1.62 (m, 2H), 1.42 (m, 2H), 1.34 (t, J=7.1 Hz, 3H), 1.21 (m, 1H).

Provenance & Evidence