3-(4-Methylpiperazin-1-yl)aniline → HCID 68677299, compound

Participants

Reaction Steps

Using the procedure outlined in Example 1 (g) the title compound was prepared from 3-(4-methyl-piperazin-1-yl)-phenylamine (from Example 37(A), 55 mg, 0.29 mmol) and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (from Example 17(e), 100 mg, 0.26 mmol). The title compound was obtained as a yellow solid (72 mg, 56%). 1H NMR (400 MHz, CDCl3) δ (ppm): 9.27 (s, 1H), 8.46 (s, 1H), 7.75 (br, 1H), 7.29 (m, 1H), 7.22 (d, J=8.5 Hz, 1H), 6.86 (m, 1H), 6.66 (d, J=8.5 Hz, 1H), 5.05 (m, 1H), 4.31 (q, J=7.1 Hz, 2H), 3.17 (t, J=4.9 Hz, 4H), 2.51 (t, J=4.9 Hz, 4H), 2.28 (s, 3H), 1.94 (m, 4H), 1.76-1.19 (m, 6H), 1.34 (t, J=7.1 Hz, 3H).

Provenance & Evidence