HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-trifluoromethyl-4-(4-trifluoromethylphenyl)-1H-pyrimidin-2-one | HCID 57468600 | — |
| Product | 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyrimidine | HCID 57468599 | — |
Reaction Steps
The title compound was prepared from 6-trifluoromethyl-4-(4-trifluoromethylphenyl)-1H-pyrimidin-2-one (8.72 g, 28.3 mmol) and phosphoryl chloride (80 mL) according to the general procedure I. Obtained as a light brown solid (9.13 g, 98%). MS (EI) 326.0 [(M)+]; mp 71.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-94fba341e9424879ad159d45912f65c6 |
| Source note | uspto-grants-2010_01 |