HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-(4-chloro-phenyl)-6-methyl-1H-pyridin-2-one | HCID 57468640 | — |
| Product | 2-Chloro-4-(4-chloro-phenyl)-6-methyl-pyridine | HCID 57468639 | — |
Reaction Steps
The title compound was prepared from 4-(4-chloro-phenyl)-6-methyl-1H-pyridin-2-one (15 g, 68 mmol) and phosphoryl chloride (31.1 mL, 341 mmol) according to the general procedure Ia to d preparation of chlorides. Obtained as a brown solid (12.3 g, 75%). MS (ISP) 238.1 [(M+H)+], 240 [(M+2+H)+] and 242 [(M+4+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-2bcc465bc4f443728b0b8abf29954f77 |
| Source note | uspto-grants-2010_01 |