HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-Cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one | HCID 57468649 | — |
| Product | 2-Chloro-6-cyclopropyl-4-(4-trifluoromethyl-phenyl)pyridine | HCID 57468648 | — |
Reaction Steps
The title compound was prepared from 6-cyclopropyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (5.0 g, 18 mmol) and phosphoryl chloride (8.2 mL, 90 mmol) according to the general procedure Ia to d preparation of chlorides. Obtained as an off-white solid (4.73 g, 88%). MS (ISP) 298.2 [(M+H)+] and 300 [(M+2+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-42ca1d9390a84c3290cd286fad15a17d |
| Source note | uspto-grants-2010_01 |