HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-(3-Methyl-4-trifluoromethyl-phenyl)-6-methyl-1h-pyrimidin-2-one | HCID 57468658 | — |
| Product | 2-Chloro-4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-pyrimidine | HCID 57468657 | — |
Reaction Steps
The title compound was prepared from 4-(3-methyl-4-trifluoromethyl-phenyl)-6-methyl-1H-pyrimidin-2-one (1.73 g, 6.45 mmol) and phosphoroxychloride (20 mL) according to the general procedure I. Obtained as a brown solid (1.4 g, 76%). MS (EI) 286.1 [(M)+]; mp 101° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-0271d0a024a34bd788fcac4cb9b1057a |
| Source note | uspto-grants-2010_01 |