HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxybromide → 2-Bromo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxybromide | HCID 24613 | — |
| Reactant | 6-Methyl-4-(4-(trifluoromethyl)phenyl)pyridin-2-OL | HCID 57468644 | — |
| Product | 2-Bromo-6-methyl-4-(4-trifluoromethyl-phenyl)-pyridine | HCID 57468646 | — |
Reaction Steps
The title compound was prepared from 6-methyl-4-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (example A.30 step 1) (118.1 g, 466.4 mmol) and phosphoryl bromide (267.4 g, 933 mmol) according to the general procedure Ia to d preparation of bromides. Obtained as an off-white solid (109.67 g, 74%). MS (ISP) 316.0 [(M+H)+] and 318.0 [(M+2+H)+]; mp 74-76° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-829addec90334b589dcf958a3163b83f |
| Source note | uspto-grants-2010_01 |