HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 2-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 68692423 | HCID 68692423 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Product | 2-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine | HCID 57468682 | — |
Reaction Steps
The title compound was prepared from 2-bromo-4-methyl-4-(4-trifluoromethylphenyl)-pyridine (example A.57) (29.0 g, 92 mmol), sodium iodide (27.5 g, 183 mmol), copper(I) iodide (0.874 g, 5 mol %) and N,N′-dimethylethylenediamine (1.3 mL, 10 mol %) in dioxane (150 mL) according to the general procedure Ia to d preparation of iodides. Obtained as alight yellow solid (32.72 g, 98%). MS (ISP) 364.2 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07642264B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-f079337481a744d793b789518dca921d |
| Source note | uspto-grants-2010_01 |