反应详情

温度

23 °C

To a solution of the above described [6-bromo-4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-methanol (4.2 g, 95%, purity 81%) and 3,4-dihydro-2H-pyran (1.4 ml, 15.4 mmol) in DCM (20 ml) at 23° C. was added a catalytic amount of p-TsOH.H2O (10 mg) and the mixture was stirred at 23° C. for 18 h. Then again 3,4-dihydro-2H-pyran (0.7 ml, 7.68 mmol) was added and stirring was continued at 23° C. for another 2 h. The entire reaction mixture was directly subjected to silica gel column chromatography with n-heptane/AcOEt to give the title compound (4.59 g, 100%, 93% purity) as a light yellow oil. MS (ISP) 418.2 [(M+H)+].

1. customat 23° C.
2. stirringstirring
3. waitwas continued at 23° C. for another 2 h
4. customThe entire reaction mixture