(3-Bromophenyl)boronic acid → HCID 57468728, compound

HRID 1989141Notes

Reaction equation

HRID 1989141 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=1.[Br:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[Br:19][C:20]1[CH:25]=[C:24]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=3)[CH:5]=[C:4]([C:15]([F:18])([F:17])[F:16])[N:3]=2)[CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 4504275HCID 4504275, compound

Product 1

HCID 57468728HCID 57468728, compound

Procedure

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-trifluoromethyl-pyrimidine (example A.1) (0.59 g, 2.0 mmol) and commercially available 3-bromo-benzeneboronic acid (0.44 g, 2.20 mmol) according to the general procedure IVa. Obtained as a white solid (0.71 g, 86%). MS (EI) 413.9 [(M)+]; mp 146° C.

Sources & evidence

ORD record
ord-4c96fbd78a3247e79a9cc2ace7cfc47f
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

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