2-Chloro-4-iodopyridine → HCID 57468729, compound

HRID 1989142Notes

Reaction equation

HRID 1989142 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10](I)[N:9]=2)=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[C:24](I)[CH:23]=[CH:22][N:21]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]=[C:10]([C:24]3[CH:23]=[CH:22][N:21]=[C:20]([Cl:19])[CH:25]=3)[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 15165112-Chloro-4-iodopyridineHCID 57468601HCID 57468601, compound

Product 1

HCID 57468729HCID 57468729, compound

Procedure

The title compound was prepared from 4-(4-chloro-phenyl)-2-iodo-6-trifluoromethyl-pyrimidine (example A.3) (1.21 g, 3.15 mmol) and commercially available 2-chloro-4-iodo-pyridine [CAS No. 153034-86-7] (765 mg, 3.2 mmol) according to the general procedure IVc protocol a. Obtained as a light yellow solid (0.53 g, 45%). MS (ISP) 369.8 [(M+H)+]; mp 151° C.

Sources & evidence

ORD record
ord-eb1c2d0bc7024d3a8070ea161d149dc6
Source dataset
uspto-grants-2010_01
Patent number
US07642264B2

Reaction notes

Loading…